Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing.
نویسندگان
چکیده
Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
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عنوان ژورنال:
- Analytical chemistry
دوره 79 17 شماره
صفحات -
تاریخ انتشار 2007